Long‑term daily multivitamin use showed no mortality benefit in nearly 400,000 generally healthy US adults.
Three large US cohorts (NIH‑AARP Diet and Health Study, PLCO, and AHS) contributed 390,124 adults (median age ~61.5 years; ~55% male) followed for over 20 years, during which 164,762 deaths occurred. Investigators compared non‑users, nondaily users, and daily multivitamin (MV) users, adjusting for extensive demographic and lifestyle factors, and used both baseline and time‑varying exposure models. In pooled analyses, daily MV use vs non‑use was associated with HR ~1.04 (95% CI 1.02–1.07) for all‑cause mortality in one model, which attenuated to 0.98 (95% CI 0.93–1.04) in a more stringent time‑varying model… effectively null. Subgroup analyses showed no consistent mortality benefit in heart disease, cancer, or cerebrovascular deaths, and in some younger participants (<55 years) HRs were slightly above 1, though still modest.
Taking a daily multivitamin for years did not help people live longer in these big, long studies… it might even slightly increase risk in some groups, though the difference is tiny.
“Multivitamin Use and Mortality Risk in 3 Prospective US Cohorts,” JAMA Network Open, PMID: 38922615.
For patients, it’s time to recalibrate expectations: daily multivitamins should not be sold as “longevity pills” for generally healthy, well‑nourished adults, as there is no signal for reduced mortality and a possible tiny increase in some subgroups. Instead, prioritise nutrient‑dense diets and targeted supplementation instead.
#longevity #healthspan #longevitymedicine #antiaging #healthyaging #nutrition #evidencebasedmedicine #clinicalresearch #medicalresearch #publichealth #longevitydoctor #medfluencer #longevityclinic #wellness #healthylifestyle #nutritionscience #multivitamin #supplements #vitamins #supplementsarenotfood #healthwarning #longevitytips #agingwell #longevityscience #lifespan #healthyliving #preventivemedicine #cardiometabolichealth #cancerprevention #strokeprevention #precisionnutrition
